--with-sequencer=yes : This tells the ALSA-driver package to build the sequencer modules for whichever soundcards for which you are building. Most people want them so you will usually want to leave it set to yes. --with-oss=yes : This tells the package to build the OSS/Free emulation modules. Again, most people want this so it's probably best to stick with yes. --with-isapnp=no : Most sound cards these days are PCI and so ISA Plug and Play support isn't needed. If you are using an ISA soundcard, it's best to say yes here. --with-cards=all : You can tell the script just to build the drivers for your particular sound card here. For full information on which drivers are available see ./configure --help. If you aren't sure which chipset your soundcard uses, have a look in CARDS-STATUS in the ALSA-driver source tree. The default specified here will build all drivers.